A) Exit from Office
The President of the Republic, Nana Addo Dankwa Akufo-Addo, has relieved the following Ministers and Deputy Ministers of their portfolios in Government, with immediate effect:
| MINISTRY | NAME | |
| 1 | Finance | Ken Ofori-Atta |
| 2 | Interior | Hon. Ambrose Dery, MP |
| 3 | Health | Hon. Kwaku Agyeman Manu, MP |
| 4 | Environment, Science, Technology and Innovation | Hon. Dr. Kwaku Afriyie, MP |
| 5 | Information | Hon. Kojo Oppong Nkrumah, MP |
| 6 | Roads and Highways | Hon. Kwasi Amoako-Atta, MP |
| 7 | Works and Housing | Hon. Francis Asenso Boakye, MP |
| 8 | Gender, Children and Social Protection | Hon. Lariba Abudu, MP |
| 9 | Local Government, Decentralisation and Rural Devt | Hon. Dan Botwe, MP |
| 10 | Sanitation and Water Resources | Hon. Freda Prempeh, MP |
| 11 | Tourism, Arts and Culture | Ibrahim Mohammed Awal |
| 12 | Greater Accra Region | Hon. Henry Quartey, MP |
| 13 | Oti Region | Mr. Joseph Makubu |
Deputy Ministers
| MINISTRY | NAME | |
| 1 | Information | Ms. Fatimatu Abubakar |
| 2 | Local Government, Decentralisation and Rural Development | Hon. Collins Ntim Aboagye, MP Hon. Martin Adjei-Mensah Korsah, MP |
| 3 | Communications and Digitilisation | Hon. Ama Pomaa Boateng, MP |
| 4 | Health | Hon. Tina Mensah, MP Hon. Mohammed Asei Seini, MP |
| 5 | Works and Housing | Hon. Abdulai Abanga, MP |
| 6 | Lands and Natural Resources | Hon. Benito Owusu Bio, MP |
| 7 | Fisheries and Aquaculture Development | Hon. Moses Anim, MP |
| 8 | Energy | Hon. William Owuraku Aidoo, MP Hon. Andrew Egyapa Mercer, MP |
| 9 | Education | Hon. Gifty Twum Ampofo, MP |
| 10 | Employment and Labour Relations | Hon. Bright Wireko-Brobbey, MP |
The President personally expressed his sincere appreciation directly to each of the Ministers and Deputy Ministers, who have exited Government, for their commitment, competence, dedication and hard work in office, which helped in the realization of Government’s mandate to the Ghanaian people over the last seven (7) years, and wished each of them well in their future endeavours.
B) New Ministerial and Deputy Ministerial Appointments
Following the re-organisation of the Government, President Akufo-Addo has submitted to Parliament, for prior approval, through the Speaker, Rt. Hon. Alban Sumana Kingsford Bagbin, the names of the following persons for appointment as Ministers and Deputy Ministers of State, in accordance with articles 78, 79 and 256, respectively, of the Constitution:
Ministers of State Designate
| MINISTRY | NAME |
| Health | Hon. Dr. Bernard Okoe Boye |
| Environment, Science, Technology and Innovation | Hon. Ophelia Mensah Hayford, MP |
| Information | Ms. Fatimatu Abubakar |
| Gender, Children and Social Protection | Hon. Dakoa Newman, MP |
| Local Government, Decentralisation and Rural Development | Hon. Martin Adjei-Mensah Korsah |
| Sanitation and Water Resources | Hon. Lydia Seyram Alhassan |
| Tourism, Arts and Culture | Hon. Andrew Egyapa Mercer, MP |
| Greater Accra Region | Hon. Titus Glover |
| Oti Region | Mr. Daniel Machator |
Deputy Ministers of State Designate
| MINISTRY | NAME |
| Information | Hon. Sylvester Tetteh, MP |
| Local Government, Decentralisation and Rural Development | Hon. Vincent Ekow Assafuah, MP |
| Communications and Digitilisation | Hon. Charles Acheampong, MP |
| Health | Hon. Adelaide Ntim, MP Hon. Alexander Akwasi Acquah, MP |
| Works and Housing | Hon. Dr. Prince Hamidu Armah, MP |
| Lands and Natural Resources | Hon. Akwasi Konadu, MP |
| Fisheries and Aquaculture Development | Hon. Musah Abdul Aziz Ayaba, MP |
| Energy | Hon. John Kobina Sanie, MP Hon. Collins Adomako Mensah, MP |
| Education | Hon. Kingsley Nyarko, MP |
| Employment and Labour Relations | Hon. Festus Awuah Kwofie, MP |
| Gender, Children and Social Protection | Hon. Benjamin Sekyere Yeboah, MP |
President Akufo-Addo is hopeful that Parliament will, once again, on a bi-partisan basis, expedite the approval of his nominees, so they can join the Government forthwith, and assist in the delivery of his mandate for his second term in office.
C) Re-assigned Ministers & Deputy Minister of State
The President of the Republic, Nana Addo Dankwa Akufo-Addo, has re-assigned the following Ministers of State and Deputy Minister of State to new offices, and has directed that they assume their respective duties with immediate effect.
Ministers of State
| MINISTRY | NAME |
| Finance | Hon. Mohammed Amin Adam, MP |
| Interior | Hon. Henry Quartey, MP |
| Roads and Highways | Hon. Francis Asenso-Boakye, MP |
| Works and Housing | Hon. Kojo Oppong Nkrumah, MP |
| Minister of State, Office of the President | Hon. Ambrose Dery, MP |
Deputy Minister of State
| MINISTRY | NAME |
| Local Government, Decentralisation and Rural Development | Hon. Abdulai Abanga, MP |
Eugene Arhin
Director of Communications Office of the President
